Detail E-Book
Principles Of Clinical Cancer Genetics: A Handbook From The Massachusetts General Hospital
Pengarang: Daniel C. Chung
Edisi: 1
ISBN/ISSN: 978-0-387-93844-8
Penerbit: Springer
Tahun Terbit: 2010
Tempat Terbit: New York, Amerika Serikat
Bahasa: English
Klasifikasi: NONE
No. Panggil: PRI
GMD: Electronic Resource
Catatan
Cancer results from the stepwise accumulation of genetic
alterations within a cell. These alterations lead to abnormal
proliferation and clonal expansion, and ultimately to inva-
sion of surrounding tissues and metastasis to distant sites.
Genetic abnormalities providing a selective advantage are
maintained and ultimately become dominant within the
population. The accumulation of genetic abnormalities,
which in most cases occurs over a period of years, underlies
both the process of tumorigenesis (the transition from nor-
mal cells to invasive cancer) and tumor progression (the
transition to a metastatic and often treatment-resistant can-
cer). Histologic correlates of the process of tumorigenesis
are recognized in a subset of cancers (e.g., colon and blad-
der cancers), whereas for others such cancer-precursor
lesions have not been identified. Dozens of genes involved
in tumorigenesis and tumor progression have now been
identified. The products of these genes regulate key cellular
processes including cell proliferation and survival, cellular
motility and differentiation, and the establishment of cellu-
lar immortality.
Daftar File
| No. | Nama File | Aksi |
|---|---|---|
| 1 | Principles of Clinical Cancer Genetics: A Handbook from the Massachusetts General Hospital |