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Pharmacoepidemiologic research is a valuable tool to enable one to understand
medication utilization patterns, beneficial/harmful outcomes of drug therapy, and to evaluate the
impact of other interventions on outcomes of drug therapy in “real-world” settings.
Objectives: This dissertation aimed to apply pharmacoepidemiologic methods to examine (1)
changes in utilization patterns of cholesterol-lowering medications following the release of the
guidelines and evidence-based data, (2) the associations between statin use and gait speed
decline in older adults, and (3) the associations between aspirin, non-aspirin nonsteroidal anti-
inflammatory drugs or acetaminophen and risk of ovarian cancer.
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