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Burger's Medicinal Chemistry and Drug Discovery, Sixth Edition is a comprehensive scientific reference work covering the fundamental principles of medicinal chemistry and advances in drug discovery and development. Edited by Donald J. Abraham, this sixth edition continues the renowned reference series originally established by Alfred Burger.

The book integrates several scientific disciplines, including organic chemistry, biochemistry, pharmacology, molecular biology, biotechnology, and pharmaceutical sciences, to explain the processes involved in discovering and developing new drug compounds. Its discussions include relationships between chemical structure and biological activity, drug design, biological target identification, compound optimization, and the development of drug candidates into therapeutic products.

The sixth edition consists of six volumes organized according to different areas of medicinal chemistry. Volume One focuses on drug discovery, including quantitative structure-activity relationships (QSAR), virtual screening, bioinformatics, and chemical information computing systems. Volume Two discusses drug discovery and development, including combinatorial chemistry, parallel synthesis, high-throughput pharmacology, and drug design approaches.

Volume Three covers cardiovascular agents and endocrines. Volume Four explores autacoids, diagnostic agents, and drugs derived from advances in modern biology. Volume Five focuses on chemotherapeutic agents, including drug development for infectious diseases and cancer. Volume Six discusses nervous system agents, including therapeutic research for Alzheimer's disease and other neurological disorders.

In addition to providing theoretical foundations, the book examines technological developments and modern approaches in pharmaceutical research, such as genomics, proteomics, bioinformatics, combinatorial chemistry, and high-throughput screening.

This reference work is particularly valuable for students of pharmacy, chemistry, biochemistry, and medicine, as well as researchers, pharmacists, medicinal chemists, pharmacologists, and pharmaceutical industry professionals involved in drug discovery, design, and development.