Catatan

This book is divided into two main sections: Part A, Standards, and Part B, Extemporaneous Preparation Formulary. Part A discusses the fundamental standards and guidelines for safe, effective, and high-quality extemporaneous medicine preparation. It covers the background and importance of extemporaneous compounding, risk management, quality management systems, personnel training, premises and equipment, documentation, preparation procedures, formulation and stability, quality control, complaints, product recalls, adverse events, procurement, and quality assessment. It also emphasizes the importance of pharmacists' responsibilities, regulatory compliance, appropriate documentation, and regular audits to minimize clinical and technical risks during the compounding process. Part B focuses on the extemporaneous preparation formulary and presents the findings of surveys conducted across several National Health Service (NHS) regions to identify the 50 most frequently compounded oral liquid medicines. It introduces a dual risk assessment approach based on technical complexity and clinical consequences associated with inaccurate dosing. Furthermore, this section provides detailed monographs for each medicine, including recommended formulations, preparation methods, beyond-use dates, pharmaceutical and clinical considerations, chemical structures, physicochemical stability profiles, and bioavailability data. Overall, this book serves as a comprehensive practical reference for pharmacists, pharmaceutical professionals, and healthcare practitioners involved in the preparation, quality assurance, and safe administration of extemporaneously compounded medicines, particularly for patients who require individualized dosage forms.