Catatan

Analgesia (Handbook of Experimental Pharmacology, Volume 177) is a comprehensive scientific volume that explores the pharmacological mechanisms of pain and the development of analgesic therapies. Pain, particularly chronic and neuropathic pain, remains a major global medical challenge because conventional pain treatments often provide only partial relief and may cause significant adverse effects, including opioid tolerance, addiction, respiratory depression, and gastrointestinal or cardiovascular complications associated with nonsteroidal anti-inflammatory drugs (NSAIDs). This book aims to provide a systematic, mechanism-based understanding of analgesia by connecting fundamental molecular biology, nociception, ion channels, and signal transduction with clinical applications and the development of new analgesic drugs. Its chapters cover the mechanisms of nociception and inflammation, including physiological and pathological pain, polymodal nociceptors, peripheral and central sensitization, and neuroimmune interactions. The book also examines major classes of analgesic drugs, including opioids and their interactions with μ, δ, and κ receptors; antipyretic analgesics and NSAIDs through COX-1 and COX-2 inhibition; local anesthetics that block voltage-gated sodium channels; and triptans acting on 5-HT1B/1D receptors for migraine treatment. Furthermore, it explores emerging molecular targets for future pain management, such as cannabinoid receptors, transient receptor potential (TRP) channels, particularly TRPV1, and peripheral opioid receptors. Overall, this volume provides valuable scientific insights into the development of more effective and safer pain management strategies, emphasizing individualized, mechanism-based therapies that target specific pain pathways while minimizing systemic adverse effects.